130111 妊娠高血圧症候群のsFlt-1とPlGF

Indicated delivery delivering a small-forgestational-age infant, HELLPなどのリスク
Rana S, Hacker MR, Modest AM, Salahuddin S, Lim KH, Verlohren S, Perschel FH,
Karumanchi SA.
Circulating angiogenic factors and risk of adverse maternal and perinatal outcomes in twin pregnancies with suspected preeclampsia.
Hypertension. 2012;60:451-8.


Antiangiogenic:  soluble fms-like tyrosine kinase-1 (sFlt-1)
高くなる

proangiogenic:  placental growth factor (PlGF)
低くなる

従って、sFlt1/PlGF ratioは上記のような合併症発生と関連がある。
sFlt-1/PlGF ratio 85 i以上が 単胎妊婦のpreeclampsia のリスク

Rana S, Powe CE, Salahuddin S, Verlohren S, Perschel FH, Levine RJ, et
al. Angiogenic factors and the risk of adverse outcomes in women with
suspected preeclampsia. Circulation. 2012;125:911–919.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319742/